The pharmacology of rocuronium bromide
نویسندگان
چکیده
Rocuronium is a new nondepolarizing neuromuscular blocking drug. Its onset of action is comparable to that of succinylcholine, with good-to-excellent intubating conditions possible 1 minute after doses two times the ED95 (600 pg/kg). The ED9a of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for adults. Rocuronium is readily reversed with conventional doses of cholinesteraseinhibiting drugs. A new agent, rocuronium possesses a very stable cardiovascular profile and a rapid onset of action. It may be useful for rapid sequence intubation without unacceptable delays in the spontaneous recovery of neuromuscular function.
منابع مشابه
Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E2 Synthesis in Endothelial Cells
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An efficient, scalable and high yielding process is developed for a neuromuscular blocking agent Rocuronium bromide 1 by studying various process parameters. The process involves simple work up and obviates column chromatography purification and usage of commercially unacceptable solvents.
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تاریخ انتشار 2008